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The principal cytochrome P450 isoenzyme included seems to be CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Around eighty five% of the oral dose seems within the urine in just 24 hrs of administration, most as being the glucuronide conjugate, with compact amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity facts.In indiv